Nutritional hypercholesterolemia increases hepatic inflammatory response to acute endotoxemia
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چکیده
منابع مشابه
The relationships among acute phase response proteins, cytokines, and enzymes during ovine experimental endotoxemia
BACKGROUND: The acute phase response is beneficial to theanimal in restoring homeostasis, and measuring the circulatingacute phase proteins, cytokines, and enzymes can be used toevaluate the innate immune system's responses to invader agentssuch as bacterial lipopolysaccharide. Measurement of theseparameters has shown to be useful as diagnostic and prognosticmarkers in animal endotoxemia. OBJEC...
متن کاملEarly endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans.
CONTEXT Sepsis-induced hypoglycemia is a well known, but rare, event of unknown origin. OBJECTIVE The aim of the study was to obtain insight into the mechanism of sepsis-induced hypoglycemia, focusing on glucose kinetics and insulin sensitivity measured with stable isotopes by using the model of human endotoxemia. DESIGN Glucose metabolism was measured during two hyperinsulinemic [insulin l...
متن کاملEndotoxemia increases relative perfusion to dorsal-caudal lung regions.
Changes in the spatial distribution of perfusion during acute lung injury and their impact on gas exchange are poorly understood. We tested whether endotoxemia caused topographical differences in perfusion and whether these differences caused meaningful changes in regional ventilation-to-perfusion ratios and gas exchange. Regional ventilation and perfusion were measured in anesthetized, mechani...
متن کاملInflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.
Endotoxin-mediated cholestasis stems from impaired hepatobiliary transport of bile acids and organic anions due to altered expression and activity of transporters, including Oatp, Mrp, Ntcp, and Bsep. However, the mechanisms by which the Oatp and Mrp genes are down-regulated are largely unknown. Using in vivo and in vitro murine models of inflammation, we examined the role of cytokines and bile...
متن کاملHepatic platelet and leukocyte adherence during endotoxemia
INTRODUCTION Liver microcirculation disturbances are a cause of hepatic failure in sepsis. Increased leukocyte-endothelial interaction, platelet adherence and impaired microperfusion cause hepatocellular damage. The time course and reciprocal influences of ongoing microcirculatory events during endotoxemia have not been clarified. METHODS Male Wistar rats (232 +/- 17 g) underwent cecal ligati...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.lb118-b